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Turning off a specific enzyme reversed prediabetes in mice

Jul 11, 2019
Scientists recently discovered that they could reverse prediabetes in obese mice by switching off an enzyme in charge of the final step of ceramide creation. When scientists switched off the enzyme called dihydroceramide desaturase 1 (DES1), they noticed how the change prevented mice from developing a fatty liver and insulin resistance, being these two the first causes of heart diseases and diabetes. Although extensive research has talked about the benefits of how the reduction of ceramide could reverse metabolic disorders and diabetes, there are some severe side effects. However, experts assured that if they continued studying and targeting the enzyme, the treatments for Type-2 diabetes, heart diseases, and metabolic conditions could improve.
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